ListenerInterfaceRequestHandler.response looks up the component on the page, but does not handle ComponentNotFoundException thrown by PageAndComponentProvider when the component does not exist. A situation where this might occur, is that the page instance is fresh and the component is added in onBeforeRender.
The attached quickstart demonstrates the problem. Copy the URL of the link at the bottom, paste it in the location bar and change the page id, simulating an expired page (ie session timeout). This will give a ComponentNotFoundException.