Currently the click handlers in zone.js return false to prevent browsers from following the link. Sometimes this result in unexpected behavior in pages.
The use-case where we have been hit by this is ajax links in a bootstrap dropdown:
When a link option is clicked the dropdown does not close again - This is due to the click event being cancelled.
The fix that we use locally; is to use event.preventDefault() and let the click event bubble.
I think this should be the default behavior of the framework - as it has much smaller impact than swallowing the click event and makes the client side things more flexible.